Researchers at Karolinska Institutet in Sweden have linked resistance to treatment for a deadly form of kidney cancer to low mitochondrial content in the cell. When the researchers increased the mitochondrial content with an inhibitor, the cancer cells responded to the treatment. Their findings, which are published in Nature Metabolism,Continuar Leyendo
A new deep learning (DL) model that can identify disease-related features from images of eyes has been unveiled by a group of Tohoku University researchers. This ‘lightweight’ DL model can be trained with a small number of images, even ones with a high-degree of noise, and is resource-efficient, meaning itContinuar Leyendo
Scientists at St. Jude Children’s Research Hospital identified a molecular mechanism that in a preclinical study unlocked the promise of CAR T-cell therapy for treatment of solid tumors. The results were published today in the journal Nature. Memphis. June 23, 2022.- «Our work extends from the basic biology of TContinuar Leyendo
In a leap forward for diabetes research, Tokyo Tech researchers reveal that the ‘feel-good hormone,’ dopamine, regulates insulin secretion through a heteromeric complex of receptors, thereby providing new targets for antidiabetic medication and therapy. The study is the first to elucidate the mechanism behind dopamine’s down-regulation of insulin secretion. Tokio,Continuar Leyendo
Scientists from the German Cancer Research Center (DKFZ) studied the human immune response after immunization with the malaria pathogen Plasmodium falciparum. Their goal was to find out against which protein components the T helper cells induced in this way are directed. To the researchers’ surprise, the T helper cells reactedContinuar Leyendo
Recommendations on how to use gene testing to prevent sudden cardiac death in athletes and enable safe exercise are published today in the European Journal of Preventive Cardiology, a journal of the European Society of Cardiology (ESC). Sophia Antipolis, June 18, 2022.- «Genetic testing for potentially lethal variants is moreContinuar Leyendo
Over-the-counter COVID tests can quickly show whether you are infected with SARS-CoV-2. But if you have a positive result, there’s no equivalent at-home test to assess how long you’re protected against reinfection. In the Journal of the American Chemical Society, researchers now report a simple, accurate glucose-meter-based test incorporating aContinuar Leyendo
Researchers at Massachusetts General Hospital (MGH) have discovered that the interferon gamma receptor (IFNgR) signaling pathway is critical for susceptibility of glioblastoma tumors to killing by CAR T-cell immunotherapy. The same phenomenon was observed in other solid tumors. This discovery may partly explain why liquid and solid tumors respond veryContinuar Leyendo
A multi-center study of more than 3,000 people with high blood pressure and brain aneurysms found that the use of RAAS inhibitors, a class of blood pressure lowering medications, reduced the risk of an aneurysm rupture by 18%, according to new research published today in Hypertension, a peer-reviewed journal ofContinuar Leyendo
Two separate findings by a University of Houston nationally recognized expert in systemic lupus erythematosus (SLE or lupus), a chronic autoimmune disease that affects multiple organs including the kidneys, skin, joints and heart, are being reported in scientific and medical journals. Houston, June 03, 2022.- Chandra Mohan, M.D., Ph.D., HughContinuar Leyendo
